Ananda Developments - Research Roundup Issue Eighteen

ANANDA DEVELOPMENTS PLC

("Ananda" or the "Company")

Ananda is an AQSE-listed medical cannabis company creating UK-based operations to grow and provide carbon zero, consistent, medical cannabis for the UK and international markets.

Medical Cannabis Research Roundup 

Issue eighteen

Summary:

In the last month there was an interesting mix of papers showing the efficacy and explaining the mechanisms of action of cannabis in a variety of indications. This included diabetes, Alzheimer's and bladder pain syndrome, as summarised below.

10:1 CBD:THC sublingual spray shows promising results in Diabetes Type 2 patients

In vitro study helps to explain mechanisms of action of CBD alleviating bladder pain syndrome

Medical cannabis use to improve functioning of Alzheimer's patients

10:1 CBD:THC sublingual spray shows promising results in Diabetes Type 2 Patients

The study investigated the efficacy and safety of a sublingual spray - comprising a combination of CBD and Δ9-THC in a 10:1 ratio (delivering 200 mg/20 mg CBD/Δ9-THC), administered two puffs each time, twice per day over an eight-week treatment period - on glycemic state and lipid profiles of patients with type II DM.

A statistically significant decline in total cholesterol, triglyceride, LDL-C, FBS, Hb A1C and insulin secretion was observable in the patients treated at the end of the 8-week treatment period. 

Regarding safety, the mentioned adjunctive regimen was well tolerated, and there were no serious or severe adverse effects. This study demonstrated that the sublingual spray could be a new therapeutic agent for lipid and glycemic control in diabetic patients.

Reference: 

A Phase I Randomized, Double-blind, Placebo-controlled Study on Efficacy and Safety Profile of a Sublingually Administered Cannabidiol /Delta 9-tetrahydrocannabidiol (10: 1) Regimen in Diabetes Type 2 Patients

https://brieflands.com/articles/ijpr-132647.html

In vitro study helps to explain mechanisms of action of CBD alleviating bladder pain syndrome 

Interstitial Cystitis (IC) or Bladder Pain Syndrome (BPS) is a chronic inflammatory disease of the urinary bladder of unknown cause. IC/BPS is associated with depression and lower quality of life. Many of those affected also have irritable bowel syndrome and fibromyalgia.  

This condition is often confusable and comorbid with other pelvic pain disorders and involves the bladder mucosa, peripheral inflammation. Treatment for the disease remains suboptimal.  

Several animal studies have described the potential effect of cannabidiol (CBD) in alleviating the symptoms of IC/BPS. 
 

This study investigated the effect of CBD against inflammation and oxidative stress in an in vitro model of IC/BPS comprised of TNFα-stimulated human urothelial cells SV-HUC1.  

Results show that CBD treatment of urothelial cells significantly decreased TNFα-upregulated mRNA and protein expression of IL1α, IL8, CXCL1, and CXCL10, as well as attenuated NFκB phosphorylation. In addition, CBD treatment also diminished TNFα-driven cellular reactive oxygen species generation (ROS).  

Observations provide new insights into the therapeutic potential of CBD through modulation of PPARγ/Nrf2/NFκB signalling pathways, which could be further exploited in the treatment of IC/BPS. 

Reference: 

Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress 

https://www.mdpi.com/1422-0067/24/5/5055  

Medical Cannabis Use Found to Improve Functioning of Alzheimer's Patients 

There are 10 million new cases of dementia reported each year worldwide. The most common symptoms of dementia are agitation and weight loss. As new treatments are being explored, medical cannabis use is increasing in patients with Alzheimer's. 

A retrospective trial looked at enhancing the clinical use of a cannabis extract for Alzheimer's patients. 30 Alzheimer's patients, aged 65-90 years old, were treated with a cannabis extract diluted in olive oil, containing 22% THC and 0.5% CBD, twice daily. Patient data was then collected from questionnaire responses over the 12-week study. 

45% of patients who were treated with MCBP improved in mental functioning. The data showed the cannabis extract reduced agitation, sleep and eating issues whilst improving caregiver stress. All patients were less physically and verbally aggressive. 

Larger patient studies, with a control and self-reported data, are needed to better understand the effects of cannabis extracts on Alzheimer's patients. 

Reference: 

Oral THC: CBD cannabis extract in main symptoms of Alzheimer's disease: agitation and weight loss 

https://pubmed.ncbi.nlm.nih.gov/36655645/  

-Ends-
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About Ananda Developments

Ananda is an AQSE-listed medical cannabis company creating UK-based operations to grow and provide carbon zero, consistent, medical cannabis for the UK and international markets.

For more information, please visit: https://anandadevelopments.com/