19 July 2021
Apollon Formulations Kill Prostate Cancer Cells
Apollon Formularies Plc (AQSE: APOL) ("Apollon" or the "Company"), a
The medical cannabis formulations were developed by Apollon Formularies Jamaica Limited ("Apollon Jamaica").
Prostate cancer is the second most frequent malignancy, after lung cancer, in men worldwide, counting 1,276,106 new cases and causing 358,989 deaths, which equates to 3.8% of all deaths caused by cancer in men, in 2018. The incidence and mortality of prostate cancer worldwide correlate with increasing age, with the average age at the time of diagnosis being 66 years. Of note, for African American men, the incidence rates are higher when compared to White men, with 158.3 new cases diagnosed per 100,000 men and their mortality is approximately twice that of White men. ⁴
According to a recent report published by Fior Markets, the global prostate cancer treatment market is expected to grow from
The testing was performed by BIOENSIS, an independent, pre-clinical predictive pharmaceutical testing laboratory. The testing results showed that Apollon Jamaica's medical cannabis formulations were effective in killing living hormone-sensitive and hormone-resistant prostate cancer cells directly (direct cytotoxicity). The formulations killed nearly 100% of the prostate cancer cells in 3D cell cultures. ⁶
The testing occurred as a part of a Joint Testing Agreement between the parties and was authorized in accordance with Apollon Jamaica's Research & Development licence issued by the Jamaican government's Cannabis Licensing Authority (CLA).
Stephen D. Barnhill, M.D., CEO of Apollon, commented, "Cannabinoids have been seen to exert 'antitumor' effects by a number of different means, including killing cancer cells directly as well as inhibiting transformed cell growth and tumor metastasis. ⁷ Apollon Jamaica, using results from its proprietary artificial intelligence-based analysis on strain genetics, has cultivated and processed certain of its proprietary medical cannabis products with cancer treatment expressly in mind. We are extremely excited that our proprietary medical cannabis formulations have been validated via independent laboratory testing to kill both hormone-sensitive and hormone-resistant prostate cancer cells in 3D cell cultures via direct cytotoxicity. This is in addition to our Apollon medical cannabis formulations killing HER2+ breast cancer cells and Triple Negative Breast Cancer (TNBC) cells in 3D cell culture as recently announced."
Dr. Herbert A. Fritsche, Chief Science Officer of Apollon, and former Professor and Director of Clinical Chemistry at the University of
Commented Mr. Paul Burke, Chairman, and CEO of Apollon Jamaica, "These Apollon formulation test results on prostate cancer and the plan to immediately begin treatments in
Apollon and Aion expect to negotiate a joint licence agreement whereby Aion's subsidiary AI Pharmaceuticals Jamaica Limited (AI Pharma) may exclusively license and use Apollon Jamaica's medical cannabis proprietary and intellectual property protected formulations to manufacture products for sale in the US and
Stephen D. Barnhill, CEO of Apollon, is also the Executive Chair of the Board of Aion Therapeutic Inc.
The Directors of the Company take responsibility for this announcement.
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About Apollon Formularies plc
Apollon Formularies plc is an international medical cannabis company headquartered in the United Kingdom. Apollon Formularies Jamaica Limited is a pharmaceutical company incorporated and operating in the Commonwealth of Jamaica and a contractual affiliate of Apollon. Apollon Jamaica is licensed by the Jamaican government's Cannabis Licensing Authority (CLA) to purchase cannabis under tripartite agreements from licensed cultivators, process, perform research and development, and sell medical cannabis therapeutic products that include legal medical cannabis in order to treat various illnesses under medical supervision.
About Aion Therapeutic Inc.
Aion Therapeutic Inc. is an international pharmaceutical, nutraceutical and cosmeceuticals business headquartered in Canada. AI Pharma is a wholly owned subsidiary of Aion that is in the business of research and development of formulations and products that utilize mushrooms (functional and ones including psilocybin), fungi, and other natural formulations from medicinal plants in a legal environment that permits such work and discoveries. AI Pharma is focused upon the development of medicinal antiviral, antimicrobial, anti-inflammatory, anti-hyperglycaemic, and anti-cancer compounds for use with the treatment of various diseases and ailments as well as general health promotion.
BIOENSIS is the solution of choice of predictive pharmacology needs led by a scientific team with more than 40 years of combined experience in preclinical pharmacology. BIOENSIS is the premiere innovator of 3D pharmacology technologies that more accurately recapitulate the microenvironment of human tissues and tumours. Their cutting-edge technology has been validated and optimized in more than 130 cell lines and primary tissues, and their flexible technology enables assay customization and optimization for additional cell lines and organ tissues. They have a demonstrated track record of unparalleled commitment to and collaboration with customers to achieve their predictive pharmacology objectives.
Stephen D. Barnhill, M.D.
Dr. Barnhill is a physician, fellowship trained in Laboratory Medicine and an expert in Artificial Intelligence (AI), an inventor on more than 40 patents globally and a pharmaceutical and biotech executive with experience as a CEO in both private and public companies in the United States and internationally. Dr. Barnhill is the Chairman and CEO of Apollon and the President and a 49% shareholder of Apollon Jamaica, which shares he holds for the benefit of Apollon. Dr. Barnhill is also the Executive Chairman of Aion and serves as a director and executive officer of AI Pharma.
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1. The BIOENSIS laboratory report
6. The BIOENSIS laboratory report