28 June 2021
Apollon Formulations Kill Triple-Negative Breast Cancer (TNBC) Cells
Apollon Formularies plc (AQSE: APOL) ("Apollon" or the "Company"), a
Metastatic triple-negative breast cancer is an aggressive form of breast cancer with limited treatment options.¹ With TNBC, the three most common types of receptors known to fuel most breast cancer growth-estrogen, progesterone, and the HER-2/neu gene, are not present in the cancer.² According to Richard Pazdur, M.D., director of the FDA's Oncology Center of Excellence and acting director of the Office of Oncologic Diseases in the FDA's Center for Drug Evaluation and Research, has stated "There is intense interest in finding new medications to help treat metastatic triple-negative breast cancer."³
Triple-negative breast cancer comprises about 10-20% of diagnosed breast cancers and is more likely to affect younger people, those of African descent, Hispanics, and/or people with a BRCA1 gene mutation.⁴ ⁵ TNBC accounts for approximately 200,000 cases each year globally.⁵ TNBC is associated with worse prognosis, early relapse after standard chemotherapy, a high frequency of metastasis to lung, bones, liver and brain, and a low overall survival compared to other breast cancer subtypes.⁶
The testing was performed by BIOENSIS, an independent, pre-clinical predictive pharmaceutical testing laboratory. The medical cannabis formulations were developed by Apollon Formularies Jamaica Limited ("Apollon Jamaica").
The testing results showed that Apollon Jamaica's medical cannabis formulations were effective in killing living triple-negative cancer cells directly (direct cytotoxicity). The Apollon medical cannabis formulations killed nearly 100% of the triple negative breast cancer cells in 3D cell cultures. ⁷
Stephen D. Barnhill, M.D., CEO of Apollon, commented, "Cannabinoids have been seen to exert 'antitumor' effects by a number of different means, including killing cancer cells directly as well as inhibiting transformed cell growth and tumor metastasis.⁸ Apollon Jamaica, using results from its proprietary artificial intelligence-based analysis on strain genetics, has cultivated and processed certain of its proprietary medical cannabis products with cancer treatment expressly in mind. We are excited that our formulations have been validated via independent laboratory testing to kill both HER2+ and triple-negative breast cancer cells in 3D cell cultures through direct cytotoxicity."
Dr. Herbert A. Fritsche, Chief Science Officer of Apollon and former Professor and Director of Clinical Chemistry at the University of
Commented Mr. Paul Burke, Chairman and CEO of Apollon Jamaica, "These Apollon formulation test results on TNBC and the plan to immediately begin treatments in
Apollon and Aion expect to negotiate a joint licence agreement whereby Aion's subsidiary AI Pharmaceuticals Jamaica Limited (AI Pharma) may exclusively license and use Apollon Jamaica's medical cannabis proprietary and intellectual property protected formulations to manufacture products for sale in the US and
The Directors of the Company take responsibility for this announcement.
Stephen D. Barnhill, CEO of Apollon, is also the Executive Chair of the Board of Aion Therapeutic Inc.
- End -
For additional information, please visit www.apollon.org.uk or contact:
Tel: +44 207 907 9314
Stene Jacobs firstname.lastname@example.org
Peterhouse Capital Limited (Corporate Adviser)
Tel: +44 207 220 9795
Guy Miller email@example.com
Blytheweigh (Financial PR/IR-London)
Tel: +44 207 138 3204
Tim Blythe firstname.lastname@example.org
Megan Ray email@example.com
About Apollon Formularies plc
Apollon Formularies plc is an international medical cannabis company headquartered in the United Kingdom. Apollon Formularies Jamaica Limited is a pharmaceutical company incorporated and operating in the Commonwealth of Jamaica and a contractual affiliate of Apollon. Apollon Jamaica is licensed by the Jamaican government's Cannabis Licensing Authority (CLA) to purchase cannabis under tripartite agreements from licensed cultivators, process, perform research and development, and sell medical cannabis therapeutic products that include legal medical cannabis in order to treat various illnesses under medical supervision.
About Aion Therapeutic Inc.
Aion Therapeutic Inc. is an international pharmaceutical, nutraceutical and cosmeceuticals business headquartered in Canada. AI Pharma is a wholly owned subsidiary of Aion that is in the business of research and development of formulations and products that utilize mushrooms (functional and ones including psilocybin), fungi, and other natural formulations from medicinal plants in a legal environment that permits such work and discoveries. AI Pharma is focused upon the development of medicinal antiviral, antimicrobial, anti-inflammatory, anti-hyperglycemic, and anti-cancer compounds for use with the treatment of various diseases and ailments as well as general health promotion.
BIOENSIS is the solution of choice of predictive pharmacology needs led by a scientific team with more than 40 years of combined experience in preclinical pharmacology. BIOENSIS is the premiere innovator of 3D pharmacology technologies that more accurately recapitulate the microenvironment of human tissues and tumors. Their cutting-edge technology has been validated and optimized in more than 130 cell lines and primary tissues, and their flexible technology enables assay customization and optimization for additional cell lines and organ tissues. They have a demonstrated track record of unparalleled commitment to and collaboration with customers to achieve their predictive pharmacology objectives.
Stephen D. Barnhill, M.D.
Dr. Barnhill is a physician, fellowship trained in Laboratory Medicine and an expert in Artificial Intelligence (AI), an inventor on more than 40 patents globally and a pharmaceutical and biotech executive with experience as a CEO in both private and public companies in the United States and internationally. Dr. Barnhill is the Chairman and CEO of Apollon and the President and a 49% shareholder of Apollon Jamaica, which shares he holds for the benefit of Apollon. Dr. Barnhill is also the Executive Chairman of Aion and serves as a director and executive officer of AI Pharma.
Disclaimer & Reader Advisory
Certain statements contained in this press release constitute forward-looking information. These statements relate to future events or future performance. The use of any of the words "could", "intend", "expect", "believe", "will", "may", "projected", "estimated" and similar expressions and statements relating to matters that are not historical facts are intended to identify forward-looking information and are based on the Company's current belief or assumptions as to the outcome and timing of such future events. Actual future results may differ materially. In particular, this release contains forward-looking information relating to the business of the Company. Various assumptions or factors are typically applied in drawing conclusions or making the forecasts or projections set out in forward-looking information. Those assumptions and factors are based on information currently available to the parties. The material factors and assumptions include regulatory and other third-party approvals; licensing and other risks. The forward-looking information contained in this release is made as of the date hereof and the parties are not obligated to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as required by applicable securities laws. Because of the risks, uncertainties and assumptions contained herein, investors should not place undue reliance on forward-looking information. The foregoing statements expressly qualify any forward-looking information contained herein.
7. Bioensis Laboratory Report